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DNA methyltransferase 1-mediated modifications exhibit bidirectional effects: hypermethylation of promoter regions in protective genes, such as ACTN4 (encoding -actinin-4), suppresses their expression, while hypomethylation of pro-pathogenic genes, including matrix metalloproteinase-9, enhances their transcription (67, 68)

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Oxidative stress is integral in driving Th17 cell differentiation by modulating key transcription factors, such as RORt, and cytokines like IL-6, IL-23, and TGF- [137]

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