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This peptide has demonstrated protective effects in preclinical models of heart failure, neurodegenerative disease, and agerelated muscle atrophy, and received FDA accelerated approval in 2025 as the first treatment for Barth syndrome [3]
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The 2025 meta-analysis by Alfalasi and colleagues, published via PMC, synthesized data from 16 studies and 6,098 total participants
Individual variation in NNMT expression NNMT expression varies significantly between individuals
Animal and human studies have found that they could reduce symptoms of diabetic neuropathy and may have neuroprotective effects as well
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