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It is important to acknowledge that the relationships we found between AC levels, MDD diagnosis, depression severity and depression profiles may be explained to some extent by shared distal environmental and lifestyle factors (e.g., comorbid somatic diseases, sedentary behavior, smoking, high-fat diet, alcohol consumption [61,62,63,64] that could act as confounder or mediators of the association
(PubMed) Zhou Y, Sinnathamby V, Yu Y, et al
Meier JJ, Gethmann A, Gtze O, Gallwitz B, Holst JJ, Schmidt WE, Nauck MA
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Systemic rather than localized gut focus: While injectables can still benefit GI health indirectly, they are not as targeted to the mucosal lining as oral forms
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