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[73] As noted above, the completely synthetic laboratory synthesis of B 12 was achieved by Robert Burns Woodward and Albert Eschenmoser in 1972, though this process has no commercial potential, requiring more than 70 steps and having a yield well below 0.01%

Pre-filled Syringes/Ampules: Convenient dosing for clinic or home use (as prescribed)

Annals of the New York Academy of Sciences, 112: 661679

Only bacteria and archaea have enzymes for its synthesis, although animals can convert it to the version they need

Some might have 500 mcg/mL or 2,500 mcg/mL

They contain high levels of a man-made version of B12 called cyanocobalamin