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It is a naturally occurring tripeptide glycyl-L-histidyl-L-lysine that binds a single copper(II) ion to form a stable complex
Constipation in the critically ill child: frequency and related factors
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IS upregulates signal transducer and activator of transcription 3 (STAT3) phosphorylation, increasing production of TGF-1, monocyte chemoattractant protein-1 (MCP-1), and -smooth muscle actin (-SMA), participating in interstitial inflammation and renal fibrosis (116)
It binds copper ions and has been studied for its role in supporting wound healing, collagen and elastin production, antioxidant defense, and the appearance of skin elasticity
References Askarpour, M., Hadi, A., Miraghajani, M., Symonds, M., Sheikhi, A., & Ghaedi, E
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