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A randomised clinical trial demonstrated that metformin improved hyperglycemia in T2D by increasing Blautia and Faecalibacterium in the gut (Tong et al., 2018)
Sugano K, Maeda K, Ohtani H, Nagahara H, Shibutani M, Hirakawa K
The long half-life (~12 days) means effects persist for weeks after discontinuation
The safety of long-term Ipamorelin use hasnt been studied in humans and there is no universal dosage determined
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