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Afamelanotide received EMA approval in December 2014 and FDA approval on 8 October 2019 , in both cases specifically to increase pain-free light exposure in adults with a history of phototoxic reactions from erythropoietic protoporphyria

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Some researchers suggest alternating nights for GHK-Cu and retinoids, or using them at different times of the day, to prevent potential irritation or reduce the efficacy of certain compounds

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