Semaglutide (Wegovy/Ozempic, Novo Nordisk) and liraglutide (Saxenda, Novo Nordisk) made up 31.4% and 35.3% of all new GLP-1 receptor agonist prescriptions in 2019, respectively
But as with many substances that generate excitement online, questions remain about whether it is safe, legal, and truly effective
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We created a propensity score to match GLP1-RA users and DDP4i users at a ratio of 1:1 using 120 characteristics selected a priori (listed in Table 1), Variables included: age, gender (self-reported), race and ethnicity (self-reported), demographics, personal history, vital signs, comorbidities, comorbidity and cardiovascular scores, frailty score, healthcare utilization, laboratory values, glucose-lowering medication classes, and other medication classes
The table summarizes their mechanisms of action, reported benefits, and experimental models used to evaluate their efficacy
[published correction appears in Obes Facts