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The common allele is cytoprotective against the toxic effects of chemotherapeutics, whereas the functionally less competent allele is thought to increase the toxicity of anticancerogenic drugs in patients with this gene variant due to decreased metabolic activity of impaired enzyme
The difference is in how long the signal stays present and what additional pathway gets activated alongside it
Jung, Y.-H., Kim, H., Kim, H., Kim, E., Baik, J., & Kang, H
[26] [27] These methodologies have been successfully applied across various functional classes, such as antimicrobial peptides, cell-penetrating peptides, and anticancer agents
TMB substrate reagent set was purchased from BD Biosciences
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