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Headache, usually resolving in the first 2 weeks

Decreases discomfort to the joints

Currently, seven AOMs are approved by both the Food and Drug Administration (FDA) and European Medicines Agency (EMA) -liraglutide, semaglutide, tirzepatide, orlistat, naltrexone/bupropion, setmelanotide, and metreleptin- while two additional agents (phentermine and phentermine/topiramate) are FDA-approved only

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Observable body composition changes require 34 weeks of protocol adherence to differentiate timing effects from natural variation