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Diabetes (2014) 63(4):122433

Premature aging due to semaglutide is often evident through rapid and disproportionate weight loss, particularly in the face and body composition

In one study, at a maximum dose of 15 mg per week, tirzepatide led to a weight loss of about 20% after one year

Insufficient caloric deficit, too much caloric intake within the eating window, medication dose not yet optimized, metabolic adaptation, or an underlying condition affecting metabolism

Excessive NNMT in the body is associated with aging and age-related diseases, as well as disruptions to systems that regulate metabolism and weight