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Importantly, increasing intracellular lactate levels, either by lactate administration or inhibition of the lactate exporter MCT4, alleviated cardiac dysfunction in these models, suggesting a potential therapeutic mechanism mediated by K1897 lactylation [18]
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Meijnikman et al., 2018) and downregulate LPS-induced pro-inflammatory mediators, such as NO, IL-6, and IL-12, resulting in anti-inflammatory effects
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