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The results come just a few weeks after a once-weekly injectable GLP-1 drug CT-388 also sourced from Carmot achieved an average weight loss of 18.8% at 24 weeks in a phase 1b trial, which the company said pointed to a potential "best-in-class" profile
[10] [11] Whilst this suggests cardiovascular benefit, the mechanisms likely involve multiple factors including improved glycaemic control, weight reduction, blood pressure lowering, and potential anti-inflammatory effects, rather than cholesterol reduction alone
Interestingly, some studies suggest that GLP-1 receptor activation also affects the nervous system
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