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Through ACSL4 induction and provision of oxidizable PUFA substrates, M1 TAMs directly enhance the lipid-peroxidation machinery necessary for ferroptosis execution

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Most of the benefit fades once you stop, because these therapies manage a condition rather than cure it

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Food and Drug Administration: Glucophage (Metformin Hydrochloride) Tablets Label JCEM Case Reports : Metformin-Associated Vitamin B12 Deficiency: An Underrecognized Complication Clinical Diabetes : Increasing Vitamin B12 Screening Among Patients With Type 2 Diabetes on Long-Term Metformin Therapy Harvard Health Publishing: Vitamin B12 Deficiency Can Be Sneaky and Harmful Johns Hopkins Medicine: Vitamin B12 Deficiency Anemia Yale Medicine: Are You Getting Enough Vitamin B12

TMAO stimulated gluconeogenesis and caused insulin resistance, which promoted the progression of diabetes (136)