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The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice [PMID: 26220769] Laboratory literature summary: The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice

The data showed that exendin-4 treatment elevated the levels of p-protein kinase B (Akt) and B-cell lymphoma 2 (Bcl-2) and suppressed the level of Bax, which indicated a lower level of cell apoptosis

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While the treatment is generally safe, certain individuals should take precautions based on their medical conditions