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Moreover, this trial found that disulfide linker lability and rapid deconjugation in MLN2704 led to significant neurotoxicity, with 44 (71%) patients experiencing dose-limiting peripheral neuropathy halting clinical development 71

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Decision Support in Medicine , 2023

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During the procedure, after sterilizing your back and administering a sedative or local anesthetic (if needed), the epidural needle is inserted