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This mechanism is primarily associated with decreased expression of synaptic-related genes, abnormal development of dendritic spines, increased apoptosis, and reduced expression of PSD95 (327329)
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Specifically for the survey, HDHP/SOs are defined as (1) health plans with a deductible of at least $1,000 for single coverage and $2,000 for family coverage 17 , offered with an HRA (referred to as HDHP/HRAs), or (2) high-deductible health plans that meet the federal legal requirements to permit an enrollee to establish and contribute to an HSA (referred to as HSA-qualified HDHPs)
Nature Reviews Clinical Oncology, 14 , 8599