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Why temperature matters for GLP-1 receptor agonists GLP-1 receptor agonists like semaglutide work by mimicking a natural hormone your gut produces after eating
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As the expression levels of OCTN2 and ATB 0,+ are higher in colon cancer cells than in normal colon cells, LC-PLGA NPs can be used to deliver chemotherapeutic drugs selectively to cancer cells for colon cancer therapy
The primary antibodies used included anti-ZO-1 (Abcam, ab307799, 1:5000), anti-Occludin (Abcam, ab216327, 1:5000), anti-ACSL4 (Abcam, ab155282, 1:10000), anti-TFR1 (ABclonal, A5865, 1:2000), anti-SLC7 A11 (Abcam, ab175186, 1:5000), anti-GPX4 (Abcam, ab125066, 1:5000), anti-VDAC2 (Proteintech, 116631-AP, 1:5000), anti-VDAC3 (Proteintech, 552601-AP, 1:5000), -tubulin (Proteintech, 100681-AP, 1:5000), and GAPDH (Proteintech, 104941-AP, 1:20000)
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Slower gut motility can increase susceptibility to conditions like SIBO, IMO, or ISO in some people, while others may tolerate GLP-1 therapy with minimal gastrointestinal impact
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