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Los Angeles Times
An interesting question is whether one of these hormones contributes more to tirzepatides effects than the other
Ipamorelins selectivity for GH release over cortisol, ACTH, and prolactin co-stimulation is conferred primarily by its Aib (-aminoisobutyric acid) substitution a non-natural alpha-methyl amino acid that constrains the peptide backbone conformation in a manner that optimises GHS-R1a engagement at somatotrophs while reducing interactions with GHS-R1a expressing hypothalamic CRH neurons responsible for ACTH/cortisol co-stimulation
Z., Miranda, A
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