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Regulatory update (August 2026): Melanotan II was not reviewed at the July 2324, 2026 PCAC hearing and has no scheduled PCAC review date as of August 2026

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Owing to its high concentration in the cell (~10 3 M) 1 , the GSH/GSSG pair acts as the main intracellular redox buffer, plays a key role in the detoxification of reactive oxygen species (ROS), and participates in redox signalling 2

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