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Your risk of hypoglycemia can increase if youre simultaneously taking a GLP-1 medication and another drug (like a sulfonylureas medication or insulin) to lower your blood sugar

How slower digestion affects your microbiome These medications dont just slow the stomach down they can also reduce movement through the small intestine

Efficacy and safety In clinical trials, patients taking retatrutide have shown an average weight loss reduction of up to 24% from baseline body weight

No studies have examined this combination specifically, but the mechanistic logic is sound

This further reduces the chance of it being interfered with by other foods or digestive processes

Others tolerate 15 mg well and benefit from the additional efficacy