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Under oxidative or nitrosative stress, GSH covalently binds to exposed cysteine thiols on enzymes, protecting them from irreversible oxidation and modulating their activity
Molecules, 28 (6), 2878
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Despite being mechanistically different, pyroptosis, ferroptosis, apoptosis, necroptosis act synergistically via shared signaling nodes in DKD, with mitochondrial ROS (mtROS) and serving as a pivotal common mediator (112, 176, 207)
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