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Researchers note that the consistency of effects across multiple substances and outcomes provides a strong rationale for dedicated clinical trials
Stokes T, Hector AJ, Morton RW, McGlory C, Phillips SM
(2024, December 20)
Additionally, several key clinical trial readouts delivered compelling data across multiple indications, for example (see Figure 1): Semaglutide : STEP-HFpEF (functional benefits in HFpEF), STEP-9 (pain reduction in knee osteoarthritis), STEP-10 (reversion to normoglycaemia in pre-diabetic, obese patients), ESSENCE (resolution of MASH, improvement in fibrosis) Tirzepatide : SUMMIT (risk reduction in HFpEF outcomes
Weeks 5 through 8: optimization phase Increase to 20 to 22.5 units daily (4.0 to 4.5mg total)
Food noise, the constant background chatter of cravings and food thoughts, begins to quiet
