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Iron overload and Hepcidin overexpression could play a key role in COVID infection, and may explain vulnerability in elderly, diabetics, and obese patients

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On the one side, p53 promotes the expression of SAT1 (Qiu et al., 2020), and then increased SAT1 cooperates with ROS to lead to lipid peroxidation (Murphy 2016), further oxidizes PUFAs, and finally causes ferroptosis

2b), in agreement with our previous characterization of this BBB model [40]

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And then there is rest: sleep and circadian rhythms, still only partly understood, appear to whisper instructions to the antioxidant system a reminder that rhythm and recovery are as vital as movement and fuel