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in Nutritional Sciences from the University of Connecticut We had him on a previous podcast (Carnivore Diet problems) Chris Recommendations for MTHFR (00:00:38) Two variants: C677T (more severe activity) & A1298C (less severe) there are 6 combinations There is a gradient of MTHFR activity across the population, evenly divided by 15-20% each Chris released a choline calculator which gives you a methylfolate score For low MTHFR activity, add an extra 1.6mg riboflavin to your diet, RDA is 1.3mg If you are doing any exercise 5 days a week, or actively losing weight, you are increasing your riboflavin needs by about 60% The best-documented thing that having low methylfolate does is increases your need for choline Cheat sheet (testing nutritional status version 1.2) There is betaine in foods and supplements, and you can partially substitute your choline requirement with it Recommendations Summary: (00:23:29) Increase your riboflavin Get more choline, take some methylfolate and creatine That will counteract the predispositions towards MTHFR Glycine (00:24:19) Glycine acts as a buffer of methyl groups Glycine is important as an inhibitory neurotransmitter When you have too little methyl groups, you excrete more glycine Methylfolate (00:26:16) Methylfolate is the off switch when you dont have enough methyl groups The ideal way to supplement is to put it in water, or take a time-release form You want the methylfolate to shut off the glycine buffering system Psychiatric disorders (00:36:32) Methylation donates methyl groups to an enzyme called COMT This regulates dopamine in ways that influence mental stability and flexibility The data is messy when youre looking at MTHFR in the psychiatric disorders COMT interacts with nutrition to impact the supply of methyl groups By impacting the relative stability and flexibility of the mind, you wind up with OCD, depression, and anxiety Homocysteine (00:39:54) What is the optimal range

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The key principle is that any combination therapy should be initiated and monitored under close medical supervision, with dose adjustments made based on glucose monitoring results and individual patient response