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For most applications, 2mL to 4mL is a functional sweet spot

For maintenance or prophylactic use (such as in a patient with short-gut syndrome who cannot absorb oral vitamins well), a common regimen is 1 mL IM once weekly

Surg Obes Relat Dis 7(5):599604 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R et al (2013) Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial

Halder, S.K

The symptoms of a more severe deficiency include anemia, which presents as fatigue, pale skin color, shortness of breath, and lightheadedness

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