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In June 2025, MBX Biosciences announced that it has submitted an IND application to the FDA for MBX 4291, a long-acting GLP-1/GIP receptor co-agonist prodrug targeting obesity, which received regulatory clearance in July
Demographics, reason for GLP-1 use, time to acute cholecystitis onset, dosage and patient outcomes were collected
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The most reliable data comes from a 2020 systematic review and meta-analysis of 37 randomized controlled trials (about 2,300 participants)
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