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For the mass spectrometry, a PRM method was employed with an included list for the masses of the metabolites of interest and their optimized normalized collision energies (Supplementary Table 4)

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Lewis adds that there have also been concerns about teratogenicity (fetal abnormalities and birth defects), but these concerns are based on animal studies with high-dose oral hydroquinone

Since only trials that used clinically relevant doses given for clinically relevant treatment periods were included in our meta-analysis, the results can be extrapolated to clinical practice

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