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Diabetic retinopathy: Rapid improvement in blood glucose control has been associated with worsening of diabetic retinopathy in people with type 2 diabetes, as observed with semaglutide
Both carry legal and quality uncertainties that a trial does not
More recently, the SUMMIT trial demonstrated that tirzepatide reduced the composite risk of cardiovascular death or worsening heart failure by 38% (HR = 0.62, 95% CI: 0.410.95) in patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 kg/m 2 , 32% of whom also had type 2 diabetes
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GHRH receptor occupancy increases baseline somatotroph activity, while Ipamorelin suppresses somatostatin tone that would normally dampen the pulse
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