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While mammalian cells and the infected mouse hosts obviously tolerated the dosage of AF used in our studies, the results presented here show that larval, juvenile, and adult parasites are extremely sensitive to killing by AF

Mitochondrial damage triggers intracellular surveillance mechanisms that promote encapsulation of impaired mitochondria by autophagosomes 37

Second, the cycling recommendation, 8-12 weeks on followed by a 4-week off period, is based on the general principle applied to peptide therapies to prevent receptor desensitization and to allow assessment of lasting effects, rather than on direct MOTS-c cycling data

The sites dosage calculator and glossary explain how half-life relates to dosing intervals in general terms

Mol Psychiatry 26 , 761771 (2021)

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