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A 12-week phase II trial of CJC-1295 in HIV-associated lipodystrophy reported one death from myocardial infarction, attributed by the attending physician to pre-existing coronary disease
The reason may be that high glutaminase expression favors rapid conversion of glutamine to glutamate for use in tricarboxylic acid cycle or bio-synthesis of nucleotides and other amino acids
Let's start with the basics
Link Kopelevich, V
We knock out Gipr in either the area postrema (AP) or hypothalamus of mice (Gipr AP-KO and Gipr hypo-KO , respectively) and compare body weight and food intake responses to GIPR agonists and antagonists, alone and in combination with the GLP-1R agonist liraglutide
however, the genetic factors influencing treatment response remain largely unexplored
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