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Key transcriptional regulators Nuclear factor erythroid 2-related factor 2 (NRF2) acts as the 'master regulator' of the cellular response to oxidative stress

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As we age, oxidative stress, genetic factors, and stem cell exhaustion cause these melanocytes to reduce melanin output or disappear entirely

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Still, its intriguing to think what each might do as a part of a mitochondrial enhancing package