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Weight reduction occurs because metformin may slightly reduce appetite and improve insulin sensitivity, allowing the body to store less excess energy as fat

Clinical outcomes associated with anti-obesity medications in real-world practice: A systematic literature review

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This broader perspective is important because obesity is not just about body weight

Had a 38% lower risk of major HF events after two years (composite of first urgent HF visit, HF hospitalization, oral diuretic intensification, and CV death)

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