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As estrogen levels fall, lean mass declines more rapidly, lowering resting metabolic rate and reducing glucose disposal capacity
In obese diabetic mice, oral elenolic acid produced a 10.7% reduction in body weight after four to five weeks, with blood glucose improvements comparable to liraglutide (Liu et al., 2024)
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[14] [15] NICE has issued technology appraisal guidance on tirzepatide for managing overweight and obesity