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vehicle-injected PNA mice, which displayed clear signs of altered cyclicity, denoted by the presence of only one generation of corpora lutea, frequently corresponding to persistent regressing corpora lutea, indicative of occasional ovulations
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An AOP maps the causal chain from a molecular initiating event (e.g., GLP-1 receptor activation) through key events at the cellular and tissue level to an adverse (or beneficial) outcome at the organism level
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