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For radiation-induced MPNST, the median survival time was 5 months for patients without surgery, 16 months for patients with complete surgical resection, 28.3% for 2-year survival, 12 months for patients with incomplete surgical resection, and 7.5% for 2-year survival

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There is no direct evidence of umami stimulation and GLP-1 secretion, but the T1R1 receptors were co-expressed with GLP-1-expressing STC-1 cells (Reference Wang, Murthy and Grider80) , which suggests that umami receptors play a role in GLP-1 signalling

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Mechanistically, stable-isotope tracing demonstrates that exogenous formate is assimilated by tumor-infiltrating CD8 T cells into the folate-dependent 1 C network, supplying 10-formyl-THF for de novo purine synthesis and thereby sustaining clonal expansion and effector programming under checkpoint pressure [71]

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