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(iii) the branched-chain -ketoacid dehydrogenase complex that is involved in the decarboxylation of ketoacids in the catabolic pathway of the branched-chain amino acids, namely leucine, isoleucine, and valine

Topical formulations (0.05%-1% concentration creams/serums) are used daily with no defined cycle limit

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MDPI Reviews, 2022)

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Each component has been independently examined in preclinical models for its potential involvement in distinct yet partly overlapping biological pathways