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Ziai SA, Larijani B, Akhoondzadeh S, Fakhrzadeh H, Dastpak A, Bandarian F,
doi:10.1159/000053183 Kwon DR, Park GY
Consequently, Meldonium's international reputation as a powerful performance enhancer appears to be built primarily on anecdotal use, theoretical biochemical mechanisms, and the inappropriate extrapolation of data from compromised animal models and ischemic patients
Overall, the above results show that senescent cells display high levels of ROS, increased Fe 2+ and alterations in lipid metabolism that prime them for ferroptosis, a fate prevented by GPX4 upregulation
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