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Bloating and early fullness are common and usually dose-related and transient

Diet and lifestyle interventions Bulking agents like dietary fiber and fiber supplementation Laxatives and stool softeners (eg, lubiprostone and polyethylene glycol) Antidiarrheals such as loperamide or bile acid sequestrants (eg, colesevelam) Antispasmodic medications (eg, pinaverium bromide) Serotonergic agents, which can be common classes of antidepressants (eg, tricyclic antidepressants [TCAs] or selective serotonin reuptake inhibitors [SSRIs]) or those that locally interact with serotonin receptors (agonists or antagonists) in the gut (eg, alosetron) Antibiotics to treat SIBO (rifaximin) What are Some Novel & Emerging Therapies for IBS

Maintaining this feedback system is important in research focused on long-term endocrine stability

While guidelines provide a framework, real-world decisions often depend on individual patient needs

Over 68 weeks, the 12 mg group lost an average of 28.7% of their body weight, equivalent to an average of 71.2 pounds