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Both BPTES and 968 were reported to be having low micromolar potency and chemical modification may be need for improvement [60]
Mohebbi for help with initial experiments
An ex vivo experimental study showed a significant accumulation of MDA in the hearts of rats exposed to the TCDD, indicating that dioxin activates ferroptosis in the tissue (Mahdi et al
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For instance, activated macrophages and T cells often exhibit heightened glycolysis and altered mitochondrial function, affecting the synthesis of NADPH and GSH (136, 137)
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