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Scale movement follows over weeks 24 as caloric deficit accumulates
Tirzepatide (Mounjaro), a dual GLP-1/GIP receptor agonist, received UK approval for type 2 diabetes and is under evaluation for obesity treatment
doi: 10.1007/s40264-020-00953-0 46 MukhtarI.AnwarH.HussainG.RasulA.NaqviS
For those who have been on medication long-term and notice a slowdown, a semaglutide plateau or tirzepatide losing effectiveness can occur
For most people it is mild to moderate and improves over the following weeks
In the STEP 1 trial published in Diabetes, Obesity, and Metabolism , participants who paired weekly semaglutide for weight loss with a structured lifestyle intervention regained an average of two-thirds of the weight theyd lost within one year after stopping both
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