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The researchers of that article went on to note that an increasing interest in the gut microbiota has emerged as a target for therapeutic strategies in obesity and overweight due to its direct relation with the aforementioned health conditions and complications

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The FDA specifically stated that our preliminary evaluation has not found evidence that use of these medicines causes suicidal thoughts or actions while the MHRA noted that the available evidence does not establish a causal relationship between GLP-1 receptor agonists and suicidal behavior, suicidal ideation, self-injury and depression. Taken together, these formal investigations did not reveal evidence of a causal relationship between the use of GLP-1s and suicidal thoughts, self-injurious behavior, or even depression

This is particularly crucial in highly secretory cells such as pancreatic -cells, where efficient insulin production depends on intact Golgi dynamics

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