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Current understanding and controversy on brain access of GLP-1 and GLP-1 receptor agonists
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The results of the FIGHT and LIVE trial in fact failed to demonstrate a protective effect of liraglutide in patients with both acute and chronic HF, respectively [121, 122]
Aside from a 27% reduction in the co-primary endpoint of CV death or HHF (largely driven by HHF reduction), dapagliflozin reduced the risk of 40% decline in eGFR to 33.9 mg/mmol), a sustained decline in eGFR of 30% or more from baseline, or chronic RRT (HR 0.85, 95% CI 0.77-0.93
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