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9,11 MTX works by irreversibly binding to and competitively inhibiting dihydrofolate reductase (DHFR), which in turn inhibits the conversion of dihydrofolate (DHF) to tetrahydrofolate (THF), resulting in reduced nucleic acid synthesis

Curcumin has a lot of health benefits

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if other NSAIDs are used, then the lowest effective dose for the shortest possible duration is recommended (Peura 2002)

It is not a true vitamin, but rather a vitamin-like substance