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DOI: 10.1186/s12970-015-0067-x
When activated, AMPK can indirectly or directly reduce the phosphorylation level of PI3K or prevent the activation of AKT to inhibit the activity of the PI3K/AKT pathway, thereby interfering with various malignant phenotypes of glioma stem cells, including proliferation, migration, invasion, and resistance to apoptosis (93)
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The gut microbiota, which comprises approximately 100150 times more genes than the human genome, is found in the human intestines and includes approximately 1000 species and 7000 types of bacteria, gram-positive or gram-negative Firmicutes (including the species Lactobacillus, Eubacterium and Clostridium), and gram-negative Bacteroidetes form the majority of the bacteria (containing Bacteroides and Prevotella ) (Flowers and Ellingrod, 2015
The Novel DA-CH3 dual incretin restores endoplasmic reticulum stress and autophagy impairments to attenuate alzheimer-like pathology and cognitive decrements in the APPSWE/PS1E9 Mouse Model
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