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The peptide showed no effect on serum IGF-1 levels, no negative effect on carbohydrate metabolism, and no immunogenicity with no anti-AOD-9604 antibodies detected
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doi:10.1038/s41574-019-0280-9
Studied in models involving nicotinamide N-methyltransferase signaling, methylation-linked metabolism, and metabolic pathway regulation
The importance of 3-AR was verified when long-term treatment with AOD9604 in 3-AR knockout mice failed to produce the changes in body weight and increase in lipolysis observed in wild-type control mice
These include serious infection, uremia or renal failure, drugs with bone marrow suppression properties (e.g., chloramphenicol), or concurrent undiagnosed folic acid or iron deficiency anemia
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