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GLP-1 (Glucagon-Like Peptide-1) medications are a class of drugs that have been shown to be effective in managing type 2 diabetes and, more recently, in promoting significant weight loss
Heres How Semaglutide Represses Appetite Semaglutides effectiveness in weight loss primarily stems from its ability to repress appetite
Third, planned surgery requiring general anesthesia
People who pair the drug with a structured nutrition approach and resistance training lose more weight and preserve more muscle mass
Honglin Jia and Zhengting Liang are cofirst authors Supplementary Information Below is the link to the electronic supplementary material
What Research Studies Have Compared These Two Medications Directly The primary direct comparison is SURMOUNT-5, a randomised controlled trial published in the New England Journal of Medicine (2025), which compared tirzepatide 10mg or 15mg against semaglutide 2.4mg in adults with obesity without diabetes over 72 weeks [10]
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