In vivo preclinical research involving rodent models assesses Dihexa's capacity to cross the blood-brain barrier following systemic administration
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Still investigational: not FDA-approved, and patient counseling must reflect this
Limitations include: Enzymatic and chemical degradation Poor membrane permeability Comparatively large molecular size When a peptide like epithalon is unmodified, bioavailability may be less than 1%
It was developed as a standardized version of compounds associated with epithalamin, a pineal extract studied in aging, sleep, and circadian rhythm research