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Role of oncometabolites in tumor progression As mentioned above, among the hallmarks of cancers, metabolic alterations are emerging as one of the most intriguing and complex therapeutic targets [21, 22] due to the strict connections of the different metabolic pathways and the capacity of cancer cells to adapt their energetic requirements on nutrient availability and microenvironmental changes

[57] The mitochondrial NADH is then oxidized in turn by the electron transport chain, which pumps protons across a membrane and generates ATP through oxidative phosphorylation

Harris et al

S.et al (2024a)

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Extremity malignant peripheral nerve sheath tumors (neurogenic sarcomas): a 10-year experience