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Given that NACA was able to counteract the effects of the ACOX1 gain-of-function mutation, antioxidant treatment was considered for patient#1 during a severe disease flare

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Jackson MJPS, Bolaos J, Bruckdorfer R, Carlssen H, Elliot RM, Flier J, Griffiths HR, Heales S, Holst B, Lorusso M, Lund E, Moskaug JO, Moser U, Di Paola M, Polidori MC, Signorile A, Stahl W, Via-Ribes J, Astley SB: Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function